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"Science Revives Extinct Dire Wolves"

Bringing a super-sized canine back from extinction after 12,500 years might sound like the plot of a thrilling movie, complete with special effects showcasing gnawed flesh and buckets of fake intestines. Yet, it's a reality that the world now faces, with three dire wolves living in a secret location
By Nicholas
Apr 20,2025

Bringing a super-sized canine back from extinction after 12,500 years might sound like the plot of a thrilling movie, complete with special effects showcasing gnawed flesh and buckets of fake intestines. Yet, it's a reality that the world now faces, with three dire wolves living in a secret location in the US, thanks to the efforts of Colossal Biosciences.

Romulus and Remus at three months old

The biotech company, driven by what some might call an extreme Game of Thrones fandom, successfully used the DNA of the common gray wolf, gene-editing, and domestic dog surrogates to bring to life Romulus, Remus, and their younger sister, Khaleesi. These dire wolves are everything a mother of dragons could dream of: huge, white, and simply awe-inspiring.

“I could not be more proud of the team. This massive milestone is the first of many coming examples demonstrating that our end-to-end de-extinction technology stack works,” said CEO of Colossal Ben Lamm.

“Our team took DNA from a 13,000 year old tooth and a 72,000 year old skull and made healthy dire wolf puppies. It was once said, ‘any sufficiently advanced technology is indistinguishable from magic.’ Today, our team gets to unveil some of the magic they are working on and its broader impact on conservation.”

Romulus and Remus at one month old

Colossal Biosciences is no stranger to making headlines. Previously, they engineered a Colossal Woolly Mouse, resembling a mammoth phenotype, using computational analysis of 59 woolly, Columbian, and steppe mammoth genomes ranging from 3,500 to over 1,200,000 years old. However, the company faces criticism, with some arguing that the dire wolves are merely normal wolves in fancy dress, suggesting that the dire wolf DNA available today is insufficient to create a true genetic clone.

The motives behind Colossal Bioscience's efforts extend beyond creating social media buzz and owning extraordinary pets. The company aims to leverage its findings to preserve current species for future generations.

“The de-extinction of the dire wolf and an end-to-end system for de-extinction is transformative and heralds an entirely new era of human stewardship of life,” said Dr. Christopher Mason, a scientific advisor and member of the board of observers for Colossal.

“The same technologies that created the dire wolf can directly help save a variety of other endangered animals as well. This is an extraordinary technological leap in genetic engineering efforts for both science and for conservation as well as preservation of life, and a wonderful example of the power of biotechnology to protect species, both extant and extinct.”

As for the dire wolves, Colossal Biosciences has collaborated with the American Humane Society and the USDA to ensure their 2,000+ acre preserve is suitable for their needs. Like any celebrities, these dire wolves are attended by a dedicated team of staff to care for them.

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